How effective is terbinafine for toenail fungus?

Overall, the study results showed that tablets are considerably more effective than nail polishes or creams. One year after a three-month treatment with terbinafine: About 17 out of 100 people who didn't have this treatment no longer had a detectable fungal nail infection.

How long does it take for terbinafine to work on toenail fungus?

Many fungal infections get better within 7 days of treatment with terbinafine – nail infections can take 3 months or more. When using terbinafine on your skin, the most common side effect is irritation in the area where you apply it.

How long should I take terbinafine for nail fungus?

For oral dosage form (tablets): For onychomycosis (fungus infections of the fingernails): Adults—250 milligrams (mg) once a day for 6 weeks.

What is the success rate of terbinafine?

Forty-eight percent achieved a clinical cure compared with only 6% of the placebo group (RR 6.00, 95% CI 3.96 to 9.08; 8 studies, 1,006 people). The mycological cure rate was 59% vs 17% with placebo (RR 4.53, 95% CI 2.47 to 8.33) though there was high variability between individual studies for this outcome.

Does toenail fungus come back after terbinafine?

A 7-year prospective study of 73 onychomycosis patients who were successfully treated (mycological and clinical cure) with continuous terbinafine or intermittent itraconazole showed that recurrence occurred at a mean time of 36 months after successful treatment [8].

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What is the number one cure for toenail fungus?

Terbinafine for toenail fungus treatment

The best pill for toenail fungus is terbinafine. Evidence suggests it works better than the alternatives with the fewest side effects. Terbinafine results in resolution of toenail fungus 76% of the time.

What should I avoid while taking terbinafine?

Avoid caffeine (coffee, soda, chocolate) while you are using this medicine. Terbinafine may cause caffeine to stay in your body longer than usual.

Is there anything stronger than terbinafine?

Itraconazole has higher clinical and mycological cure rates as compared to terbinafine.

Is it worth taking terbinafine?

Terbinafine has an average rating of 6.3 out of 10 from a total of 456 ratings on Drugs.com. 55% of reviewers reported a positive experience, while 33% reported a negative experience.

How common is liver damage from terbinafine?

Clinically apparent liver injury from terbinafine occurs rarely (1 in 50,000 to 120,000 prescriptions), but many case reports and even case series have been described in the literature. Liver injury usually arises within the first 6 weeks of therapy.

How do I know if my toenail fungus is healing?

Does terbinafine penetrate the nail?

Knowledge of the pharmacokinetics of terbinafine and itraconazole have resulted in original, but contrasting, advice over the timing of oral therapy. Both drugs penetrate nail plate rapidly and persist in nail for some time.

What does terbinafine do to your nails?

Terbinafine granules are used to treat fungal infections of the scalp. Terbinafine tablets are used to treat fungal infections of the toenails and fingernails. Terbinafine is in a class of medications called antifungals. It works by stopping the growth of fungi.

Can toenail fungus be completely cured?

Fungal nail infections typically don't go away on their own, and the best treatment is usually prescription antifungal pills taken by mouth. In severe cases, a healthcare professional might remove the nail completely. It can take several months to a year for the infection to go away.

Why is terbinafine hard on your liver?

Like many drugs, terbinafine is metabolised by the liver and excreted by the kidneys, consequently a reduction in function of either of those two organ systems could result in serious problems if prescribed to the wrong patient.

Why does it take so long to get rid of toenail fungus?

Toenail fungus can be tough to get rid of because it can get into and in between those layers. It may also sit on top of the nail or grow underneath it. In some cases, fungus can get into the cells that make the nail, called the nail matrix.

How many months can you take terbinafine?

You will usually take the tablets for anywhere from 6 weeks to 3 months. But, if you have a nail infection of the big toe or your nails grow very slowly, you may need to take the tablets for up to 6 months.

Are there long term effects of terbinafine?

Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.

What is the best time of day to take terbinafine?

Timing: Take terbinafine tablets at the same time each day, either in the morning OR in the evening. You can take terbinafine with or without food. Missed dose: If you forget to take your dose, take it as soon as you remember that day.

Is terbinafine hard on kidneys?

The clinical history combined with the diagnostic findings suggest acute kidney injury and rhabdomyolysis associated with terbinafine use.

How long does it take terbinafine pills to work?

How long does it take for Terbinafine to work? The duration and efficacy of treatment depend on the type of fungal infection. Typically, terbinafine takes 4 to 6 weeks in cases of ringworm and athlete's foot. However, nail infections take a little longer to heal – between 6 to 12 weeks.

What can I take instead of terbinafine?

Can I take vitamin D with terbinafine?

Interactions between your drugs

No interactions were found between terbinafine and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can fungus become resistant to terbinafine?

Trichophyton rubrum resistant to terbinafine

Oral terbinafine is considered the first-line treatment for most infections caused by this organism, but cases of terbinafine-resistant T. rubrum are increasingly being reported. Researchers have reported cases of difficult-to-treat terbinafine-resistant T.

Does terbinafine cause weight loss?

This medicine may cause problems with your sense of taste or smell. Tell your doctor right away if you or your child have change or loss of sense of smell, change in taste or loss of taste, poor appetite, or weight loss. You may become depressed when taking this medicine.