Is Lamisil hard on the liver?

Terbinafine is an oral and topical antifungal medication commonly sold under the brand names Lamisil and Terbinex. The oral medication form may cause liver damage.

Is liver damage from Lamisil reversible?

Terbinafine-induced liver injury has been reported in the literature. 2-5 The majority of the cases are reversible after discontinuation of the drug. There is at least one report of acute liver failure due to this drug.

What are the dangers of taking Lamisil?

Tell your doctor right away if you have any serious side effects, including: vision changes, mental/mood changes (such as depression), unexplained bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine). Terbinafine may rarely cause serious (possibly fatal) liver disease.

How long does it take for terbinafine to damage liver?

Clinically apparent liver injury from terbinafine occurs rarely (1 in 50,000 to 120,000 prescriptions), but many case reports and even case series have been described in the literature. Liver injury usually arises within the first 6 weeks of therapy.

How do I know if terbinafine is affecting my liver?

Any symptoms of persistent nausea, anorexia, fatigue, vomiting, right upper abdominal pain or jaundice, dark urine, or pale stools must be reported. Patients with these symptoms should discontinue taking the drug, and the patient's liver function should be immediately evaluated.

Will Antifungals That Treat Toenail Fungus Hurt My Liver?

How quickly can Lamisil damage your liver?

If liver injury does occur, it usually happens within the first 6 weeks of taking terbinafine.

How often does Lamisil affect liver?

It goes on to state that clinically apparent liver injury from terbinafine occurs rarely, in around 1 in 50,000 to 120,000 prescriptions.

How common is liver damage with antifungals?

In a large meta-analysis of antifungals tolerability and hepatotoxicity, the risk of liver injury with standard dose of fluconazole not requiring treatment discontinuation was 9.3%, while the risk of drug discontinuation due to elevated liver enzymes was 0.7% [74].

What should I avoid while taking Lamisil?

What drugs and food should I avoid while taking Lamisil (Terbinafine)? Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medicine. Avoid exposure to sunlight or tanning beds. Terbinafine can make you sunburn more easily.

Is it worth taking terbinafine?

Terbinafine has an average rating of 6.3 out of 10 from a total of 456 ratings on Drugs.com. 55% of reviewers reported a positive experience, while 33% reported a negative experience.

What are 3 side effects of Lamisil?

Is Lamisil worth taking?

Lamisil has an average rating of 6.8 out of 10 from a total of 136 ratings on Drugs.com. 60% of reviewers reported a positive experience, while 27% reported a negative experience.

Is Lamisil hard on your body?

The adverse events reported encompass gastrointestinal symptoms (including diarrhea, dyspepsia, and abdominal pain), liver test abnormalities, rashes, urticaria, pruritus, and taste disturbances. Changes in the ocular lens and retina have been reported following the use of Lamisil Tablets in controlled trials.

How long should you be on Lamisil?

You will usually take the tablets for 2 to 6 weeks. This depends on the type of infection you have and how serious it is. If you have a fungal nail infection, you will probably need to take the tablets for several months. These infections take a while to clear.

What is the success rate of Lamisil?

(Lamisil vs Itraconazole in ONychomycosis) study found that mycologic cure rates (76 vs 38% of patients after 12 weeks' treatment; 81 vs 49% of recipients after 16 weeks' therapy) and complete cure rates were approximately twice as high after terbinafine treatment than after itraconazole (3 or 4 cycles of 400 mg/day ...

Do antifungal creams affect the liver?

Most antifungal agents have been implicated in causing some degree of hepatotoxicity; clinically apparent liver injury with jaundice occurs most prominently with ketoconazole, fluconazole, voriconazole, and terbinafine.

How long does it take for Lamisil to work on skin fungus?

It may take several weeks after treatment for the infection to completely heal. Inform your doctor if your condition worsens or does not improve within 2 weeks for jock itch and ringworm and within 4 weeks for athlete's foot.

How long do you have to take Lamisil for toenail fungus?

Typical dosing for Lamisil (terbinafine)

Fungal nail infection: Take 1 tablet (250 mg) by mouth once a day. If you are using this for a fingernail infection, you will take Lamisil (terbinafine) for 6 weeks. If you are using this for a toenail infection, you will take Lamisil (terbinafine) for 12 weeks.

When should you not use Lamisil?

DO NOT use Lamisil AT 1% Cream if you: are allergic (hypersensitive) to any of the ingredients in the product (see Section 6). The cream is NOT recommended for use on children under 16 years of age. The cream is for external use only.

Which antifungal is safest?

The antifungals fluconazole and itraconazole are considered relatively safe; they have been associated with only minor changes in liver function tests that usually do not require interruption of treatment. Fluconazole is widely used in the treatment of various fungal infections.

Why are antifungals so toxic?

For example, the 2 most common classes of antifungal agents, polyenes and azoles, target the synthesis of the cell membrane, a structure shared by both mammalian and fungal cells, and thus these drugs have inherent toxicity.

What drug most commonly causes liver failure?

1) Acetaminophen (Tylenol)

Acetaminophen works well as a fever reducer and pain reliever but is one of the most common causes of medication-related liver failure. Of the liver failure cases attributed to medications, more than a third are due to acetaminophen.

What can I take instead of terbinafine?

What foods should I avoid while taking terbinafine?

Do not use applesauce or fruit-based foods. If you will need two packets of oral granules with each dose, you may sprinkle the content of both packets on one spoonful or two spoonfuls of non-acidic food. Avoid caffeine (coffee, soda, chocolate) while you are using this medicine.

Can you take Lamisil with fatty liver?

The possibility of liver disease (hepatotoxicity) with terbinafine has long been known and drug manufacturers have highlighting that it should not be prescribed for patients with liver disease.