Is propofol better than general anesthesia?

Propofol isn't versus general anesthesia; rather, propofol is a widely used drug that can be used to induce and maintain general anesthesia, but also for lighter sedation for procedures like colonoscopies. General anesthesia (GA) is the state of complete unconsciousness for major surgery, while propofol offers rapid onset, quick recovery, less nausea (fewer "hangover" effects), and precise control, making it ideal for both deep sedation and full GA, often combined with other agents for balanced anesthesia.

Is propofol safer than general anesthesia?

Propofol isn't inherently "safer" than general anesthesia; it's a powerful drug used within general anesthesia or deep sedation, offering faster recovery and less nausea but carrying risks like respiratory/blood pressure drops, requiring expert monitoring (anesthesiologists) to manage these side effects, making it safe when administered correctly, but risky if misused. While it offers benefits like less post-op sickness compared to some inhaled agents, its rapid action means users can quickly go from sedation to complete respiratory arrest, hence strict guidelines. 

How to give propofol to a dog?

Propofol is dosed at 1.5 to 4 mg per pound (3 to 8 mg/kg) intravenous, given slowly over 1 minute. For constant infusion, propofol is dosed at 0.05 to 0.3 mg per pound per minute (0.1 to 0.6 mg/kg/min).

What are the disadvantages of propofol?

The primary concern with propofol toxicity is the development of fatal conditions. Hypertriglyceridemia can lead to pancreatitis. Metabolic acidosis can develop, leading to other derangements. Cardiac failure and rhabdomyolysis are significant concerns for propofol toxicity.

Can propofol cause tongue swelling?

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

The power of propofol

How do they wake you up from propofol?

They wake you up from propofol by simply stopping the continuous infusion; because it's a fast-acting drug rapidly cleared by the body, your consciousness returns quickly, usually within minutes, as it's metabolized by the liver and redistributed from the brain. Medical staff closely monitor you in recovery, ensuring vital signs are stable as you wake up, sometimes using other medications like caffeine in research or helping with breathing support if needed, though typically just turning off the drip is enough. 

What is the 10 8 6 rule for propofol?

Traditionally, one such popular algorithm is the “10-8-6 rule” used for adult infusions. The rule includes a loading does of propofol at 1 mg/kg followed by an infusion of 10 mg/kg/hr for a period of 10 minutes, then 8 mg/kg/hr for the next 10 minutes, and finally 6 mg/kg/hr for the subsequent time period.

What famous person died from propofol?

On June 25, 2009, the American singer Michael Jackson died of acute propofol intoxication in Los Angeles, California, at the age of 50.

What is the most abused drug by anesthesiologist?

Opioids remain the most commonly misused medication by ACPs, but propofol misuse is also common and increasing in incidence.

What is the 7 second rule for dogs?

The "7-Second Rule" for dogs is a simple test for hot pavement: place the back of your hand on the surface for seven seconds; if it's too hot for you to keep your hand there comfortably, it's too hot for your dog's paw pads and can cause burns, so walk on grass or wait for cooler times. Dark surfaces like asphalt get much hotter than air temperature and can seriously harm dogs' paws.
 

What is the 2 4 6 rule for anesthesia?

The 2-4-6 rule for anesthesia is a guideline for preoperative fasting, indicating how long patients should abstain from food and drink before surgery to prevent aspiration (inhaling stomach contents): 2 hours for clear liquids, 4 hours for breast milk, and 6 hours for formula or light meals, with heavier meals requiring longer (often 8+). This evidence-based rule, established by the American Society of Anesthesiologists (ASA), replaces older "NPO after midnight" mandates, allowing for shorter, safer fasting times for most healthy patients. 

What is the 3-3-3 rule for dog anxiety?

The 3-3-3 rule for dog anxiety is a guideline for adopting a new dog, suggesting 3 days to decompress (overwhelmed, hiding), 3 weeks to learn routines (personality emerges, some testing), and 3 months to feel truly at home (secure, bonded). This rule provides realistic expectations for patience and consistency, acknowledging that a dog's adjustment is a gradual process of building trust and security in a new environment, reducing anxiety over time.
 

What is the least risky anesthesia?

The safest type of anesthesia is generally local anesthesia, which numbs a small, specific area and lets you stay awake, having the fewest side effects and fastest recovery. Regional anesthesia (like spinal/epidural) is also very safe, blocking larger areas. While general anesthesia (total unconsciousness) carries more risks, it's often necessary for complex surgeries and is extremely safe due to modern monitoring and an expert team, with risks more tied to procedure/health than the anesthetic itself.
 

Do you get a breathing tube with propofol?

Monitored anesthesia care (MAC) or deep sedation: This method typically involves propofol. It, too, is delivered through an IV but will be administered by the anesthesia team. It does not normally require a breathing tube.

What does propofol do to the brain?

Propofol works by enhancing the brain's main inhibitory neurotransmitter, GABA, leading to widespread brain depression, sedation, and unconsciousness by dampening neural communication, especially between the thalamus and cortex, altering brain rhythms to slow frequencies and disrupting the normal balance of excitation/inhibition. It effectively reduces brain activity, causing temporary loss of awareness but also affecting breathing and blood pressure.
 

Why was Michael Jackson not able to sleep?

Insomnia. Allan Metzger stated in his testimony for Murray's trial that Jackson began having recurring insomnia because each show often left him adrenalized and unable to sleep for days. Metzger would prescribe sleep medication for Jackson that helped him while he was working on We Are the World.

What is the saddest death of a famous person?

There's no single "saddest" death, as it's subjective, but Robin Williams, Princess Diana, Chadwick Boseman, and Freddie Mercury are frequently cited due to their profound impact, tragic circumstances (suicide, accident, illness), and the widespread grief they caused, often described as losing a loved one or a global figure whose loss created a huge void. Other heartbreaking losses include Steve Irwin, David Bowie, Prince, and those from early music eras like Buddy Holly, showing varied reasons for profound sadness. 

What was the last word Michael Jackson said before he died?

Michael Jackson's reported last words, according to his doctor Conrad Murray, were pleas for "milk," his nickname for the surgical anesthetic Propofol, saying, "Please, please give me some milk," as he couldn't function without sleep for his upcoming tour, followed by, "And I don't want them to cancel it, but they will have to cancel it," indicating distress about his performances being halted, before he passed from cardiac arrest due to the drug mix on June 25, 2009.
 

How quickly does propofol knock you out?

Propofol starts working very quickly, usually in less than a minute. It is also a very short-acting medicine, wearing off in 5 to 20 minutes. Most procedures will require more than one dose. For long procedures, the medicine may be given through the IV during the whole test time.

How much propofol is given during a colonoscopy?

This was similar to the nurse-administered propofol sedation (NAPS) technique described by Rex et al (3), who noted that the dose of propofol required to initiate the colonoscopy may vary from 30 to >200 mg. If the patient seemed to experience discomfort during the procedure, a 10- to 20-mg bolus was delivered.

What drug wakes you up from propofol?

Active Emergence from Propofol General Anesthesia Is Induced by Methylphenidate.

What is the cocktail they give you before surgery?

Feinstein: Anesthesiologists sometimes tell patients that they are getting a "cocktail" of medications prior to their procedure, which can sound mysterious and intriguing, when in reality this cocktail is typically just comprised of a single medication called midazolam.

How to calm anxiety before surgery?

To calm pre-surgery anxiety, use deep breathing, meditation, and distraction with music or reading, while also talking to your medical team about concerns and potentially asking for anti-anxiety medication; focusing on the positive outcomes, staying informed, and avoiding caffeine, smoking, and alcohol are also key strategies for a calmer experience.