Is terbinafine hard on kidneys?

The clinical history combined with the diagnostic findings suggest acute kidney injury and rhabdomyolysis associated with terbinafine use.

Can terbinafine cause permanent damage?

Most cases of acute hepatic injury from terbinafine resolve within 3 to 6 months of stopping the medication. In some instances, however, the injury is severe and unremitting, leading to acute liver failure and either death or need for liver transplantation.

What should I avoid while taking terbinafine?

Avoid caffeine (coffee, soda, chocolate) while you are using this medicine. Terbinafine may cause caffeine to stay in your body longer than usual.

Does Lamisil affect kidneys?

Kidney function: The safety and effectiveness of using terbinafine have not been determined for people with decreased kidney function. The kidneys are partially responsible for removing terbinafine from the body. Decreased kidney function may cause terbinafine to build up in the body causing side effects.

Can you take terbinafine long term?

For some infections, such as fungal nail infections, you may need to take terbinafine tablets for up to 3 months (sometimes longer). It is safe to take long-term if your doctor tells you to.

Supplement concerns for kidney disease patients: Mayo Clinic Radio

Is it worth taking terbinafine?

Terbinafine has an average rating of 6.3 out of 10 from a total of 456 ratings on Drugs.com. 55% of reviewers reported a positive experience, while 33% reported a negative experience.

What can I take instead of terbinafine?

Can antifungal cause kidney failure?

Many patients who receive antifungal agents are immunocompromised or critically ill. This leaves many of these patients prone to renal failure, especially following transplantation.

Is terbinafine the best antifungal?

The oral antifungal drug terbinafine appears to be slightly better than alternative 'azole' drugs for treating fungal toenail infection.

How do I know if terbinafine is affecting my liver?

Any symptoms of persistent nausea, anorexia, fatigue, vomiting, right upper abdominal pain or jaundice, dark urine, or pale stools must be reported. Patients with these symptoms should discontinue taking the drug, and the patient's liver function should be immediately evaluated.

How long should I take terbinafine for toenail fungus?

Terbinafine is usually taken for 6 weeks to treat scalp or fingernail infections, and for 12 weeks to treat a toenail infection. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Should I stop taking terbinafine?

Since fungal infections may be very slow to clear up, you may need to take this medicine for several weeks or months. If you stop taking this medicine too soon, your symptoms may return. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses.

Is liver damage from terbinafine reversible?

Terbinafine-induced liver injury has been reported in the literature. 2-5 The majority of the cases are reversible after discontinuation of the drug. There is at least one report of acute liver failure due to this drug.

What does terbinafine do to the body?

Terbinafine is also sometimes used to treat ringworm (fungal infections of the skin that cause a red scaly rash on different parts of the body) and jock itch (fungal infection of the skin in the groin or buttocks). Talk to your doctor about the risks of using this medication for your condition.

Are terbinafine tablets safe?

As with most classes of drugs, terbinafine can potentially lead to liver problems. However, the data from the above suggests that oral terbinafine is safer than perhaps it is perceived, and minor side effects are far more likely for most patients than serious liver damage.

What happens if you drink coffee while taking terbinafine?

Avoid caffeine (coffee, soda, chocolate) while you are using this medicine. Terbinafine may cause caffeine to stay in your body longer than usual.

What is the best time of day to take terbinafine?

Timing: Take terbinafine tablets at the same time each day, either in the morning OR in the evening. You can take terbinafine with or without food. Missed dose: If you forget to take your dose, take it as soon as you remember that day.

How long does it take for terbinafine to work on skin fungus?

Typically, terbinafine takes 4 to 6 weeks in cases of ringworm and athlete's foot. However, nail infections take a little longer to heal – between 6 to 12 weeks.

Which antifungal is safe in renal disease?

Because of this, Liposomal Amphotericin B should be preferred to conventional Amphotericin B in the management of suspected or proven fungal infections in immunocompromised patients with preexisting renal dysfunctions, Amphotericin B induced toxicity, or failure to respond to conventional Amphotericin B.

What drugs affect the kidneys the most?

NSAIDS, or nonsteroidal anti-inflammatory drugs like ibuprofen (Advil, Motrin) and naproxen (Aleve), lead the list for drugs that cause kidney damage because of their widespread use.

Can kidneys recover from medication damage?

Most episodes of drug-induced renal impairment are reversible. Renal function generally returns to baseline provided the impairment is recognized early and the offending medication is discontinued.

Why is terbinafine obsolete?

The Food and Drug Administration (FDA) posted a discontinuation notice for Lamisil (terbinafine HCl; Novartis) tablets 250mg. The Company stated the permanent discontinuation was a business decision and is not due to manufacturing, product quality, safety, or efficacy concerns.

What is the most effective treatment for toenail fungus terbinafine?

The best pill for toenail fungus is terbinafine. Evidence suggests it works better than the alternatives with the fewest side effects. Terbinafine results in resolution of toenail fungus 76% of the time. Common side effects may include headaches, skin rash, and vomiting.

How long does it take for terbinafine to damage liver?

If liver injury does occur, it usually happens within the first 6 weeks of taking terbinafine.

How common is liver damage with antifungals?

In a large meta-analysis of antifungals tolerability and hepatotoxicity, the risk of liver injury with standard dose of fluconazole not requiring treatment discontinuation was 9.3%, while the risk of drug discontinuation due to elevated liver enzymes was 0.7% [74].