What damage can statin drugs do?

Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.

What are the side effects of taking statins for a long time?

Can statins cause permanent damage?

Often the only way to halt the effects of statins on your muscle cells is to stop taking the medications. Symptoms tend to disappear within 3 months after you stop taking statins, with no permanent damage in most cases. But a 2018 study suggests that in rare cases, some muscle damage isn't reversible.

Can statin damage be reversed?

The majority of muscle damage by statins is secondary to its direct toxic effects, possibly via coenzyme Q10 depletion causing mitochondrial dysfunction. The injury is dose dependent and reversible after withdrawing the drug, with most recovery of symptoms occurring within 2–3 months (3).

Are statin drugs worth the risk?

If you have high cholesterol and are at high risk for cardiovascular disease, you should consider statins. That's because the benefits of statins greatly outweigh the risks. Statins reduce the risk of serious cardiovascular events like heart attack or stroke by up to 25%, and death by 10%.

Statin Side Effects | Atorvastatin, Rosuvastatin, Simvastatin Side Effects & Why They Occur

What is the downside of statins?

While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.

What can I take instead of statins to lower cholesterol?

How do you know if you have muscle damage from statins?

Rhabdomyolysis or milder forms of muscle inflammation from statins can be diagnosed with a blood test measuring levels of the enzyme creatinine kinase. If you notice moderate or severe muscle aches after starting to take a statin, contact your doctor.

Which muscles are most affected by statins?

Within a month of starting statin therapy, they may feel aches or weakness in the large muscles of their arms, shoulders, thighs or buttocks on both sides of the body. About 5 to 10% of people who try statins are affected. It's more common in the elderly, in women and in those taking the more potent statins.

Can you stop a statin Once you start?

If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.

What is the best statin with the least side effects?

According to a research review people who take simvastatin (Zocor) or pravastatin (Pravachol) may experience fewer side effects.

Why do statins have to be taken at night?

So, why do people take statins at night? Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.

Why do patients stop taking statins?

Dr. Carimi says muscle-related complications are the most common side effect from taking statins. “The most common reason people stop taking statins is because of side effects, like muscle aches, but many have muscle pains from other causes and stop taking the medication in error,” Dr. Carimi says.

How long does it take for statins to damage liver?

Statin-associated hepatocellular injury frequently occurs 5 to 90 days after the initiation of therapy. Bilirubin levels more than twice the ULN imply severe hepatocellular liver injury with a mortality of 10% and an incidence of 0.7–1.3 per 100,000 cases of drug-induced liver injury (DILI).

Do cardiologists recommend statins?

Those guidelines recommend statins for adults ages 40 to 75 who have a 7.5% or greater risk of having a heart attack or stroke in the next 10 years, as opposed to a 10% risk.

How do I get off statins?

What organ do statins affect?

Statins work by reducing the amount of cholesterol made by the liver and helping the liver remove cholesterol that is already in the blood. Statins may also reduce inflammation in the artery walls. This can lead to blockages that damage organs such as the heart and brain.

What are the two most common adverse effects of statins?

Side effects can vary between different statins, but common side effects include: headache. dizziness.

What is the best statin that doesn't cause muscle pain?

Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.

What blood tests check for statin damage?

Your doctor will carry out a blood test to measure a substance in your blood called creatine kinase (CK), which is released into the blood when your muscles are inflamed or damaged. If the level of CK in your blood is more than 5 times the normal level, your doctor may advise you to stop taking the statin.

Do statins weaken leg muscles?

Skeletal muscle side effects that are associated with statin use involve muscle cramping, soreness, fatigue, weakness, and, in rare cases, rapid muscle breakdown that can lead to death (ie, rhabdomyolysis). Side effects have been associated with all commonly used statins and are dose dependent.

What is the new cholesterol medication for 2022?

The randomized controlled trial (RCT) of bempedoic acid with cardiovascular endpoints isn't expected to be completed until the end of 2022. The other new medicine is inclisiran, which is a subcutaneous injection given twice a year in the office, after initially being given at baseline and then at 3 months.

What is the first drug of choice for cholesterol?

Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes. You take a tablet once a day. You usually need to take them for life.

What is a natural substitute for statin drugs?

Should I or shouldn't I take statins?

Statins should be taken with caution if you're at an increased risk of developing a rare side effect called myopathy, which is where the tissues of your muscles become damaged and painful. Severe myopathy (rhabdomyolysis) can lead to kidney damage. Things that can increase this risk include: being over 70 years old.