What is the best statin drug on the market?

Rosuvastatin and atorvastatin are the best at lowering LDL cholesterol.

What is the safest and most effective statin?

Which cholesterol-lowering drug is the safest? Overall, statins are safe as a class of drugs. Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor^®) and pravastatin (Pravachol^®) seem to be safer and better tolerated than the other statins.

Which statin has the fewest side effects?

In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications.

What is the newest statin drug?

Leqvio is an adjunct treatment to a balanced diet and statins for lowering LDL. People take an initial dose, another dose in 3 months, and then doses twice a year.

What statin is better than Lipitor?

Both Lipitor and Crestor are excellent medications to help improve high cholesterol and to decrease your risk of heart attacks and strokes. In studies, Crestor was more effective at lowering total cholesterol levels and raising HDL levels (Jones, 2003).

Choosing a statin drug

Which statin is safest for liver?

It turns out that some statins may be better at preventing liver cancer than others. Specifically, lipophilic statins (those that dissolve more readily in lipids such as oils and fats) may be more effective for preventing liver cancer than hydrophilic statins (those that dissolve more readily in water).

Which statin should be taken every night?

These statins are best taken at night. Simvastatin, pravastatin & fluvastatin are statin's that work better if taken in the evening. Studies show that when simvastatin is taken at night, there is a greater reduction in LDL cholesterol than when the statin is taken in the morning. Lovastatin should be taken with dinner.

What is the new cholesterol medication for 2022?

The randomized controlled trial (RCT) of bempedoic acid with cardiovascular endpoints isn't expected to be completed until the end of 2022. The other new medicine is inclisiran, which is a subcutaneous injection given twice a year in the office, after initially being given at baseline and then at 3 months.

What is the new cholesterol drug that is not a statin?

In studies, Nexletol also appears to reduce the risk of muscle pain, a common complaint of people on statins. Nexletol (bempedoic acid) is a new cholesterol-lowering drug.

Which statin has the longest half life?

We elected to use rosuvastatin in an EOD regimen because its half-life of approximately 19 hours is the longest of available statins, and it is the most potent statin at reducing LDL-C levels. Atorvastatin also has a long half-life (~14 h) and has demonstrated effectiveness with EOD dosing.

Is there a new statin without side effects?

Another newer option is actually a statin. It's called pitavastatin, or Livalo. It has the same LDL- and total cholesterol-lowering property as all the other statins, but somehow doesn't give the muscle aches. A lot of people have had a lot of success taking this over any of the other statins out there.

What is the best statin that doesn't cause muscle pain?

Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.

What is the first drug of choice for cholesterol?

Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes. You take a tablet once a day. You usually need to take them for life.

What works better than statins?

Fibrates such as clofibrate (Atromid-S), fenofibrate (Antara, Fenoglide, Lipofen, TriCor, Triglide, Trilipix), and gemfibrozil (Lopid) mostly help your heart by reducing the amount of blood fat (called triglycerides) and raising “good” HDL levels.

Which statin causes the least muscle damage?

Try a different statin

The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches. If you haven't tried a hydrophilic statin, talk to your doctor about switching to one.

Can you get off statins once you start?

If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.

What is the downside of statins?

While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.

What to do if you can't tolerate statins?

Fibrates. Doctors often prescribe a fibrate for patients who can't take a statin. Like the statins, fibrates reduce the body's cholesterol production, but they are less effective in lowering LDL cholesterol levels.

Why did they take Lipitor off the market?

Type 2 diabetes -- Lipitor may increase your blood sugar, which could lead to the development of type 2 diabetes. Even though the risk is low, the Food & Drug Administration (FDA) considered it serious enough to include a warning regarding raised blood sugar and diabetes on all statin medication.

What are the top 5 cholesterol medications?

What is the new treatment for cholesterol?

Inclisiran will only be given to people who are unable to lower their cholesterol with statins and/or lifestyle changes, or are unable to tolerate statin medication.

When is the best time of day to take statins?

You can choose to take it at any time, as long as you stick to the same time every day. This prevents your blood levels from becoming too high or too low. Sometimes doctors may recommend taking it in the evening. This is because your body makes most cholesterol at night.

Which is better Crestor or Lipitor?

The study concluded that Crestor lowered LDL cholesterol by 8.2% more than Lipitor, and Crestor lowered total cholesterol significantly more than all the other statins studied. Crestor also increased HDL cholesterol (the good kind of cholesterol) more than Lipitor did.

Can I take a statin every other day instead of every day?

As evident from periodic liver enzyme estimations, we can say that alternate-day statin therapy is at least as safe as daily treatment regime. While there was one instance of myalgia, on daily atorvastatin treatment, alternate-day dosage of the same was well tolerated.

How long does it take for statins to damage liver?

Statin-associated hepatocellular injury frequently occurs 5 to 90 days after the initiation of therapy. Bilirubin levels more than twice the ULN imply severe hepatocellular liver injury with a mortality of 10% and an incidence of 0.7–1.3 per 100,000 cases of drug-induced liver injury (DILI).