Who should not use propofol?

Propofol is contraindicated for patients with a known hypersensitivity to the drug itself or its components. Specific contraindications and populations who must avoid propofol include:

What patients should not be given propofol?

Allergy to eggs, egg products, soybeans, or soy products, history of—Should not be used in patients with this condition.

• Brain or nerve problems (eg, head injury, stroke, or seizures), history of or.
• Diabetes or.
• High fat or cholesterol in the blood or.
• Infection (eg, sepsis), severe or.

Can propofol cause tongue swelling?

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What is the number one side effect of propofol?

Adverse Effects

Transient local pain at the injection site is the most common adverse reaction. This may be decreased by administering IV lidocaine before propofol bolus.

Why is propofol a high risk medication?

It has dose-dependent effects, leading to higher blood pressure and heart rate changes at higher doses. The initial administration can cause pain at the injection site. Though propofol has a generally favorable profile as a sedative, administration of toxic doses can have harmful effects.

The power of propofol

What famous person died from propofol?

On June 25, 2009, the American singer Michael Jackson died of acute propofol intoxication in Los Angeles, California, at the age of 50.

What is the 10 8 6 rule for propofol?

Traditionally, one such popular algorithm is the “10-8-6 rule” used for adult infusions. The rule includes a loading does of propofol at 1 mg/kg followed by an infusion of 10 mg/kg/hr for a period of 10 minutes, then 8 mg/kg/hr for the next 10 minutes, and finally 6 mg/kg/hr for the subsequent time period.

How many days does propofol stay in your system?

Propofol leaves the bloodstream very quickly (minutes to an hour), but its effects and traces can linger, with consciousness usually returning in 10-15 minutes; however, metabolites can stay detectable in urine for days or weeks, and impaired coordination might persist for 24 hours, requiring someone to drive you home, despite feeling alert sooner. 

What organ does propofol affect?

There are three organ systems affected by propofol: the cardiovascular system, the CNS, and the respiratory system. Propofol affects the cardiovascular system by decreasing systemic blood pressure.

Is propofol safe for the elderly?

Abstract. It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia.

How to know if allergic to propofol?

Propofol allergy symptoms range from mild (rash, itching, flushing) to severe anaphylaxis (difficulty breathing, wheezing, throat/face swelling, dizziness, rapid heart rate), requiring immediate medical help, with swelling of the face, lips, tongue, or throat being a critical sign. Other signs can include chest tightness, confusion, or changes in blood pressure, but some symptoms might relate to Propofol Infusion Syndrome (PRIS), a separate serious complication, so prompt reporting to a doctor is crucial. 

What medications can you not take with propranolol?

Tell your doctor if you're taking:

• other medicines for high blood pressure. ...
• other medicines for an irregular heartbeat such as amiodarone or flecainide.
• other medicines which can lower your blood pressure. ...
• asthma or chronic obstructive pulmonary disease (COPD) medicines.

How long will I feel weird after propofol?

Propofol may interfere with your ability to think, focus, and react for some time after receiving general anesthesia. But in most cases, mild side effects are temporary and will go away within a few hours.

What age is contraindicated for propofol?

Children Under 18 Years of Age Propofol is contraindicated for the sedation of children 18 years or younger receiving intensive care. Dosage and rate of infusion should be individualized: Adult Patients • For initiation, most patients require an infusion of 0.005 mg/kg/min (0.3 mg/kg/h) for at least 5 minutes.

What is the death risk of propofol?

The chance of having propofol infusion syndrome is about 1.1% for people given propofol infusions. It is more common in men than women. The death rate varies between 18% and 32%, according to different studies.

What are the restrictions after propofol?

Propofol sedation is increasingly being used for endoscopy in the outpatient setting. Patients are advised not to drive themselves home after endoscopic procedures that involve propofol sedation, and to refrain from driving or taking public transportation unassisted for at least 24 hours.

What is the most severe side effect of propofol?

What side effects does propofol have? It can cause a decrease in blood pressure, it can depress or even stop breathing, and it can cause pain on injection.

Where do they inject propofol?

Propofol is given intravenously (through a vein) by an anesthetist (a doctor who specializes anesthesia).

How do they wake you up after propofol?

They wake you up from propofol primarily by stopping the infusion, as the drug is cleared from your body very quickly (minutes), allowing you to regain consciousness naturally, with staff providing extra oxygen and monitoring vitals for a smooth transition in the recovery room until you're alert and stable. 

What drugs interact with propofol?

The metabolism of Propofol can be decreased when combined with Amlodipine. Amobarbital may increase the hypotensive activities of Propofol. The metabolism of Propofol can be decreased when combined with Amodiaquine. The risk or severity of CNS depression can be increased when Amoxapine is combined with Propofol.

What does it feel like to be sedated with propofol?

Propofol sedation feels like falling asleep very quickly and deeply, with most people having no memory of the procedure, often described as the "milk of amnesia" because of its rapid, pleasant, but forgettable effects, leading to a fast, clear-headed recovery without grogginess, though you might feel dizzy or confused briefly afterward, needing someone to drive you home. 

How much propofol is normal for a colonoscopy?

This was similar to the nurse-administered propofol sedation (NAPS) technique described by Rex et al (3), who noted that the dose of propofol required to initiate the colonoscopy may vary from 30 to >200 mg. If the patient seemed to experience discomfort during the procedure, a 10- to 20-mg bolus was delivered.

How quickly does propofol knock you out?

Propofol starts working very quickly, usually in less than a minute. It is also a very short-acting medicine, wearing off in 5 to 20 minutes. Most procedures will require more than one dose. For long procedures, the medicine may be given through the IV during the whole test time.

How does propofol affect the brain?

Propofol works by enhancing the brain's main inhibitory neurotransmitter, GABA, leading to widespread brain depression, sedation, and unconsciousness by dampening neural communication, especially between the thalamus and cortex, altering brain rhythms to slow frequencies and disrupting the normal balance of excitation/inhibition. It effectively reduces brain activity, causing temporary loss of awareness but also affecting breathing and blood pressure.