Why is coming off antidepressants so hard?

A person may experience withdrawal symptoms due to chemical changes in the brain. The body adjusts to changes that an antidepressant such as Zoloft may cause. Stopping or reducing the antidepressant can throw the brain into a state of imbalance. This can have a physical and mental impact.


How long does it take to feel normal after antidepressants?

Withdrawal symptoms usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more. See your doctor if you get severe withdrawal symptoms after you stop taking antidepressants.

Which antidepressants are hardest to wean off of?

In fact, antidepressant labels often warn that stopping the medication too quickly may lead to bothersome symptoms.
...
Hardest-to-Stop Antidepressants
  • citalopram) (Celexa)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)
  • sertraline (Zoloft)


What helps with antidepressant withdrawal?

When experiencing withdrawal symptoms or antidepressant discontinuation syndrome, increasing physical exercise or changing the diet to include more fresh food may help ease symptoms by making a person feel reinvigorated and less lethargic.

Does your brain ever go back to normal after antidepressants?

If the symptoms develop later or gradually, they may constitute a relapse of the depression. Ultimately, these withdrawal symptoms will improve with time, but they can be unpleasant for days and possibly even weeks. In time, the brain readjusts and people should experience a return to their normal state.


Coming off antidepressants | Animated Short Film



Is it OK to take antidepressants for life?

And luckily, as long as the benefits of the medication outweigh the potential side effects, there's no strong evidence that long-term use of SSRIs poses any major problems. “These medications have been around for decades,” says Dr. Jin Hee Yoon-Hudman, a psychiatrist and medical advisor at Minded.

Are all antidepressants hard to get off at?

The few studies of antidepressant withdrawal that have been published suggest that it is harder to get off some medications than others. This is due to differences in the drugs' half-life — the time it takes the body to clear the medication once the pills are stopped.

How do I detox my brain from antidepressants?

Antidepressant detox involves gradually stepping down doses until the user can safely stop taking them. To be able to taper off an antidepressant medication successfully, we want to do it slowly. So, it can take a month or six weeks or two months. But we just simply step the dose down slowly over time.


Does Benadryl help antidepressant withdrawal?

If you were on a very high dose of Paxil (paroxetine) or Effexor (venlafaxine), you may need to take repeated doses of Prozac. Benadryl (diphenhydramine) is an over-the-counter allergy medication that has been reported to help with discontinuation symptoms too, though it has a sedating effect.

Can you quit depression meds cold turkey?

Antidepressant withdrawal is possible if you abruptly stop taking an antidepressant, particularly if you've been taking it longer than four to six weeks. Symptoms of antidepressant withdrawal are sometimes called antidepressant discontinuation syndrome and typically last for a few weeks.

When do antidepressant withdrawals peak?

Initial symptoms appear in some individuals within 1-3 days following an abrupt discontinuation of the medication. The symptoms typically last 1-3 weeks and will typically peak within the first week. Symptoms can be relieved within 24 hours by restarting the antidepressant medication.


Why do I feel worse after stopping antidepressants?

Antidepressant discontinuation syndrome, also called antidepressant withdrawal, occurs when a person abruptly stops taking antidepressant medication. Many people who experience antidepressant withdrawal feel like they have the flu or a stomach bug. They may also experience disturbing thoughts or images.

What it feels like to wean off antidepressants?

Discontinuation symptoms often include physical complaints that aren't commonly found in depression, such as dizziness, flulike symptoms, and abnormal sensations. Discontinuation symptoms disappear quickly if you take a dose of the antidepressant, while drug treatment of depression itself takes weeks to work.

How long does antidepressant discontinuation syndrome last?

Antidepressant discontinuation syndrome is common

Symptoms occur within two to four days after drug cessation and usually last one to two weeks (occasionally may persist up to one year). If the same or a similar drug is started, the symptoms will resolve within one to three days.


How long does it take for serotonin levels to return to normal after SSRI?

In cases where serotonin syndrome is only present in a mild form, symptoms may be alleviated within 24 hours of discontinuing the medication causing the uptake in serotonin. However, some antidepressants can cause symptoms to last longer as serotonin levels may take weeks to return to normal.

How do you fix discontinuation syndrome?

Recommends 4-week withdrawal and reinstating drug then more gradually reducing it in severe cases of the syndrome. Also suggests substitution and treatment of benzodiazepines for those patients with extreme symptoms. A review of the clinical evidence of the SSRI discontinuation syndrome.

What is a natural anti depressant?

Natural antidepressants include SAM-e, St John's Wort, and omega-3-fatty acids, among others. If a person thinks they have symptoms of depression, they should speak to a doctor before trying any natural antidepressants.


How long does the average person stay on antidepressants?

The length of treatment varies.

Even once you do start to feel better, you should expect to remain on your antidepressant for at least 4 to 6 additional months. Those experiencing depression for the first time may require even longer, from 6 to 12 months.

Do you have to stay on antidepressants your whole life?

Do I have to take antidepressants forever is a question that some ask as they struggle with depression. This is one of the more common myths associated with the condition. You do not need to take antidepressants forever nor do you need to get a prescription from a counselor or therapist.

How to live without antidepressants?

Several treatments can be used instead of antidepressants for treating depression and other mental health conditions.
  1. Talking therapies. Cognitive behavioural therapy. ...
  2. Exercise. ...
  3. Self-help groups. ...
  4. Lithium. ...
  5. Electric shock treatment.


What happens if you take antidepressants for years?

Those who had used antidepressants for >3 years reported more severe side effects, including “weight gain”, “addiction”, “feeling not like myself ”, “withdrawal symptoms”, and “suicidality”, than those who had been on antidepressants for ≤2 years.

What counts as a depressive episode?

During these episodes, symptoms occur most of the day, nearly every day and may include: Feelings of sadness, tearfulness, emptiness or hopelessness. Angry outbursts, irritability or frustration, even over small matters. Loss of interest or pleasure in most or all normal activities, such as sex, hobbies or sports.

What happens to the brain after stopping antidepressants?

Brain zaps, which reportedly feel like "an electrical sensation in the brain," could occur after someone stops taking antidepressants. Though there is not a lot of research on the side effect, one study published in 2022 in The Primary Care Companion for CNS Disorders offered more insight into the sensation.


Can getting off antidepressants cause brain fog?

Unfortunately, Rickers says even with a doctor's help, tapering off an antidepressant can be notoriously difficult and come with a cocktail of bothersome side effects, like fatigue, brain fog and more.

Is it normal to cry when stopping antidepressants?

Different antidepressants will have different discontinuation side effects. Psychiatric symptoms of discontinuation such as anxiety and agitation, crying spells, or irritability are also sometimes misdiagnosed as a depressive relapse.